The former Melbourne school principal has been handed over to Australian authorities and is en route to Australia via Frankfurt on Monday, VoiCSA chief executive Manny Waks confirmed to AAP.

The Jerusalem Post reported that Leifer left earlier in the day, just hours before the closure of Israel's airports due to the coronavirus pandemic.

Pictures published by local media show Leifer about to board a flight surrounded by people wearing personal protective gear including masks and face shields.

She is expected to arrive later on Monday.

One of her alleged victims, Dassi Erlich, also tweeted on Monday that "Leifer is on the way back to Australia".

Leifer is wanted in Australia on 74 charges of child rape and sexual abuse stemming from her time as principal at Melbourne's Orthodox Addas Israel School.

Mr Waks said it was unclear how long Leifer's case would take to progress through Victoria's legal system given COVID-19 delays.

"We expect that Leifer's return to Australia will impact many people," he said in a statement.

"VoiCSA remains committed to helping anyone who may have been sexually abused by Leifer."

Israel's Supreme Court approved her extradition order in December and Justice Minister Avi Nissenkorn approved the order the following day.

In a tweet Mr Nissenkorn wrote on Monday: "I promised that I would not hinder the extradition order, and that's what I have done. Malka Leifer's victims will finally earn an act of justice."

Leifer's final failed appeal followed 74 hearings in Israeli courts, which have been drawn out on the basis of Leifer claiming mental illness.

Leifer fled Australia to Israel in 2008 when the allegations arose, using a plane ticket allegedly paid for by the Addas School.

Leifer was first arrested in Israel in 2014 and placed under house arrest, only to be let free again on the condition she undertook psychiatric assessments.

Following an independent undercover investigation that proved she was feigning mental illness and going about her life as normal, Leifer was arrested again in 2018.

Zionist Federation of Australia President Jeremy Leibler welcomed the footage of Malka Leifer boarding a plane.

"This protracted saga to have Leifer extradited to return to Melbourne to face trial has, it seems, finally ended", he said.

"That Leifer was allowed to escape justice for so long was a travesty.

"That she is coming is largely due to the tireless efforts of Dassi Erlich and her sisters, as well as their support network", Mr Leibler said.

Lifeline 13 11 14

beyondblue 1300 22 4636

Australian Associated Press